C/T conversion alters interleukin-1A promoter function in a human astrocyte cell line

Establishment a CHO Cell Line Expressing Human CD52 Molecule

Background: CD52 is a small glycoprotein with a GPI anchor at its C-terminus. CD52 is expressed by Normal and malignant T and B lymphocytes and monocytes. There are detectable amounts of soluble CD52 in plasma of patients with CLL and could be used as a tumor marker. Although the biological function of CD52 is unknown but it seems that CD52 may be involved in migration and activation of T-cells...

1638 a Human Ebv - B Cell Line Secretes Interleukin

The activation of T lymphocytes for antigen-induced proliferative responses (1), T lymphocyte cytotoxicity (2), delayed-type hypersensitivity (3), and helper function for antibody responses (4) requires their recognition of the nominal antigen on the surface of an antigen-presenting cell (APC) 1 bearing Ia-DR molecules encoded by the I region of the major histocompatibility locus. In addition t...

Modulatory effect of purified peptide isolated from Mesobouthus epeus Scorpion Venom on Astrocyte Cell line (1321N1)

Development of a Stable Cell Line, Overexpressing Human T-cell Immunoglobulin Mucin 1

Background: Recent researches have demonstrated that human T-cell immunoglobulin mucin 1 (TIM-1) glycoprotein plays important roles in regulation of autoimmune and allergic diseases, as well as in tumor immunity and response to viral infections. Therefore,targeting TIM-1 could be a potential therapeutic approach against such diseases. Objectives: In this study, we aimed to express TIM-1 protein...

Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line

Background: A possible mechanism by which hyperthermia enhances tumor immunogenicity is the induction of NKG2D ligands on tumor cells. Although the expression of MHC class I chain-related protein A and B (MICA/B) has previously been reported in different carcinomas, there is no information about MICA/B expression in liposarcomas. Objective: To investigate MICA/B induction in a human liposarcoma...